AAAS

aladin WD repeat nucleoporin

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000291836
UniProt:
Q9NRG9
OMIM:
605378

Cilia effects upon perturbation of AAAS

Cilia number / % ciliated:
No effect
Loss-of-function effect:
No effect

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.34) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Shorter Cilia (Area per Cilia z=-3.12) PMID:20393562

Subcellular localization

centrosome, flagella, nucleus

References: PMID:25613900

Functional category

  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • Metabolism
  • Viral interactions
  • Transcription regulation

Function

AAAS has localized in flagella.