AATF

apoptosis antagonizing transcription factor

Ensembl:
ENSG00000276072, ENSG00000275700
UniProt:
Q9NY61
OMIM:
608463
Synonyms:
BFR2, CHE-1, CHE1, DED

Cilia effects upon perturbation of AATF

Cilia number / % ciliated:
Decreased cilia number

Ciliogenesis screen results (5 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=3.45, ciliated=64.1%) PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-4.10) PMID:41160700

Phenotypes

Mouse phenotype:
hyperactivity, preweaning lethality, complete penetrance, embryonic lethality prior to organogenesis

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Transcription regulation

Function

Apoptosis Antagonizing Transcription Factor (AATF) localizes to primary cilia, and its depletion results in reduced ciliation of renal epithelial cells.AATF is a regulator of primary cilia and a modulator of the DNA damage response, connecting two pathogenetic mechanisms in nephronophthisis and related ciliopathies(PMID: 30770218).