ABHD2

abhydrolase domain containing 2, acylglycerol lipase

Ensembl:
ENSG00000140526
UniProt:
P08910
OMIM:
612196
Synonyms:
LABH2

Cilia effects upon perturbation of ABHD2

Ciliogenesis screen results (5 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=2.76, ciliated=58.7%) PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Longer Cilia (Area per Cilia z=7.74) PMID:20393562

Subcellular localization

flagella

Functional category

  • Reproduction & sperm
  • Protein processing & maturation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

ABHD2 localized in the flagella of human sperm and found that this enzyme also follows CatSper distribution (30184496).