ABLIM1

actin binding LIM protein 1

Ensembl:
ENSG00000099204
UniProt:
O14639
OMIM:
602330
Synonyms:
ABLIM, LIMAB1, LIMATIN

Cilia effects upon perturbation of ABLIM1

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
decreased circulating glucose level, increased bone mineral density, abnormal bone structure, decreased circulating potassium level, increased lean body mass, decreased thermal nociceptive threshold, increased bone mineral content, abnormal bone mineralization
Mouse ciliopathy phenotype:
eye hemorrhage

Subcellular localization

flagella

Functional category

  • Actin & cytoskeleton regulation

Function

ABLIM1 localized to flagella(25613900).

Model organism evidence

Danio rerio (1 reference)

miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics.

PMIDs: 22684256