ACACA

acetyl-CoA carboxylase alpha

Ensembl:
ENSG00000278540
UniProt:
Q13085
OMIM:
613933
Synonyms:
ACAC, ACAC1, ACACALPHA, ACC, ACC-ALPHA

Cilia effects upon perturbation of ACACA

Overexpression effect:
Reduced cilia numbers

Ciliogenesis screen results (7 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Failler/Valderrama et al. 2021 (siRNA) [siRNA]: Negative Regulator (Ciliogenesis Candidate) PMID:33206585
  • Kim et al. 2010 (siRNA) [siRNA]: Shorter Cilia (Area per Cilia z=-2.83) PMID:20393562
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.21) PMID:41160700

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly
  • Metabolism

Function

In the second experiment, we transfected MDCK cells with expression constructs encoding FASN and acetyl-CoA carboxylase, which are the two downstream targets of nSREBP1c that catalyze fatty acid synthesis. Expression of FASN- and acetyl-CoA carboxylase significantly reduced the percentage of ciliated cells from 79% for control cells to 27% for FASN- and acetyl-CoA carboxylase–transfected cells (20889723)