ACE2
angiotensin converting enzyme 2
- Ensembl:
- ENSG00000130234
- UniProt:
- Q9BYF1
- OMIM:
- 300335
- Synonyms:
- ACEH
Cilia effects upon perturbation of ACE2
- Cilia number / % ciliated:
- No effect
- Loss-of-function effect:
- No effect
- Overexpression effect:
- No effect
Ciliogenesis screen results (3 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Phenotypes
- Mouse phenotype:
- increased total body fat amount, abnormal thymus morphology, decreased lean body mass, abnormal spleen morphology, enlarged spleen, enlarged thymus
- Mouse ciliopathy phenotype:
- hydrometra, abnormal lens morphology, enlarged heart, abnormal uterus morphology, abnormal heart morphology, abnormal reti morphology
Subcellular localization
cilia
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- Metabolism
- T cell biology
- Viral interactions
- Protein processing & maturation
- Signaling (Hedgehog, GPCRs, ion channels)
- Cardiac & muscle development
- Muscle contraction & physiology
Function
ACE2 receptor protein robustly localizes within the membrane of the motile cilia of airway epithelial cells, which likely represents the initial or early subcellular site of SARS-CoV-2 viral entry during host respiratory transmission.