ACOT7

acyl-CoA thioesterase 7

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000097021
UniProt:
O00154
OMIM:
602587
Synonyms:
ACH1, ACT, BACH, CTE-II, HBACH, LACH1, MGC1126

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-10.92) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

No ciliary localization reported (cilia-associated gene).

Functional category

  • Ciliary assembly/disassembly
  • Cardiac & muscle development

Function

Presence of primary cilia is also validated using immunofluorescence in the stroma and muscle cells of the mouse colon, using known markers of the primary cilia. Acot7 is identified as a primary cilium associated marker and found to be expressed in myenteric ganglia.