ACOX1

acyl-CoA oxidase 1

Ensembl:: ENSG00000161533
UniProt:: Q15067
OMIM:: 609751
Synonyms:: PALMCOX

Cilia effects upon perturbation of ACOX1

Loss-of-function effect:: Longer cilia

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: increased grip strength, decreased body length, decreased grip strength, decreased thigmotaxis, decreased bone mineral density, preweaning lethality, incomplete penetrance
Mouse ciliopathy phenotype:: abnormal liver morphology, male infertility, female infertility

Subcellular localization

cilia associated gene

Functional category

Ciliary assembly/disassembly

Function

Disruption of additional peroxisomal β-oxidation-related genes, including ABCD1, ACOX1, TYSND1, and HSD17B4, markedly impaired primary ciliogenesis under serum deprivation conditions(40102401).

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