ACTA2

actin alpha 2, smooth muscle

Ensembl:: ENSG00000107796
OMIM:: 102620
Synonyms:: ACTSA

Cilia effects upon perturbation of ACTA2

Phenotypes

Mouse phenotype:: decreased basophil cell number; decreased lymphocyte cell number; decreased heart weight; decreased mean corpuscular volume

Subcellular localization

cilia associated

Functional category

Cardiac & muscle development
Metabolism
Cilia???cytoskeleton/adhesion links

Function

Treatment of healthy fibroblasts (non-fibrotic) with profibrotic TGF-β1 induced PC shortening, whereas silencing ACTA2 in systemic sclerosis (SSc) skin fibroblasts caused PC elongation. Importantly, we found that PC length was negatively correlated with αSMA levels in TGF-β1-treated healthy fibroblasts and pharmacologically dedifferentiated myofibroblasts(40958676).

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.