ACTR2

actin related protein 2

Ensembl:: ENSG00000138071
UniProt:: P61160
OMIM:: 604221
Synonyms:: ARP2

Cilia effects upon perturbation of ACTR2

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-3.15) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia associated gene, cytosol

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
Actin & cytoskeleton regulation
Viral interactions
Signaling (Hedgehog, GPCRs, ion channels)

Function

ACE2 receptor protein robustly localizes within the membrane of the motile cilia of airway epithelial cells, which likely represents the initial or early subcellular site of SARS-CoV-2 viral entry during host respiratory transmission (33116139).

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