ACTRT1

actin related protein T1

Ensembl:
ENSG00000123165
UniProt:
Q8TDG2
OMIM:
300487
Synonyms:
AIP1, ARIP1, ARP-T1, KIAA0705

Cilia effects upon perturbation of ACTRT1

Loss-of-function effect:
Shorter cilia
Overexpression effect:
Shorter cilia

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.59) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=650, lfc=0.36) PMID:30270045

Ciliopathy associations

  • Bazex-Dupré-Christol Syndrome

Subcellular localization

basal body, cilia

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Cilia length regulation

Function

Actin-Related Protein-Testis1 (ARP-T1)/ACTRT1 participates in the regulation of cilia length and that ARP-T1-associated BDCS is a case of skin cancer with ciliopathy characteristics.Overexpression of mutant ACTRT1 (547_548insA) reduced ciliary length by ~25%.Knockdown of ACTRT1 by shRNAs reduced ciliary length by ~25–50% depending on cell line and shRNA(33972689).