ADAM17
ADAM metallopeptidase domain 17
- Ensembl:
- ENSG00000151694
- UniProt:
- P78536
- OMIM:
- 603639
- Synonyms:
- CD156B, CSVP, TACE
Cilia effects upon perturbation of ADAM17
Ciliogenesis screen results (4 screens)
- Kim2016: Not Reported
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.11) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Phenotypes
- Mouse phenotype:
- hyperplasia, preweaning lethality, incomplete penetrance, extramedullary hemopoiesis, abnormal vibrissa morphology
Subcellular localization
cilia associated gene
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- T cell biology
- Neurogenesis & migration
- Viral interactions
- Protein processing & maturation
- Cell migration & adhesion
- Signaling (Hedgehog, GPCRs, ion channels)
- Axon guidance & growth
Function
Also known as tumor necrosis factor (TNF)-α-converting enzyme (TACE). Metalloprotease, cleaves Notch receptor when glycosylated by GALNT11 to control formation of motile and non-motile cilia at the node. Heterotaxy gene (24226769). Cleaves ACE2, found in respiratory cilia membrane (15983030)