ADAM9

ADAM metallopeptidase domain 9

Ensembl:
ENSG00000282230, ENSG00000168615
UniProt:
Q13443
OMIM:
602713
Synonyms:
CORD9, KIAA0021, MCMP, MDC9, MLTNG

Cilia effects upon perturbation of ADAM9

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=3.89, ciliated=67.4%) PMID:26595381

Ciliopathy associations

  • Cone-Rod Dystrophy

Subcellular localization

cilia, lysosomes

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Protein processing & maturation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Two disintegrin and metalloprotei se domain-containing proteins, ADAM9 and ADAM22, localized in cilia membranes(24748648).