ADCY2

adenylate cyclase 2

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000078295
UniProt:
Q08462
OMIM:
103071
Synonyms:
AC2, HBAC2, KIAA1060

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
increased circulating hdl cholesterol level

Subcellular localization

cilia, ciliary tip

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Metabolism
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

ADCY2 has localized in ciliary tip, primary cilia.