ADCY8

adenylate cyclase 8

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000155897
UniProt:
P40145
OMIM:
103070
Synonyms:
AC8, ADCY3, HBAC1

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

References: PMID:18687752

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Metabolism
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Transcription regulation

Function

P2Y(12) purinergic receptor, adenylyl cyclases (i.e., AC4, AC6, and AC8), and protein kinase A (i.e., PKA RI-beta and PKA RII-alpha regulatory subunits), exchange protein directly activated by cAMP (EPAC) isoform 2, and A-kinase anchoring proteins (i.e., AKAP150) are expressed in cholangiocyte cilia.