ADCY8
adenylate cyclase 8
- Ensembl:
- ENSG00000155897
- UniProt:
- P40145
- OMIM:
- 103070
- Synonyms:
- AC8, ADCY3, HBAC1
Cilia effects upon perturbation of ADCY8
Ciliogenesis screen results (3 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Subcellular localization
cilia
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- Metabolism
- Viral interactions
- Signaling (Hedgehog, GPCRs, ion channels)
- Transcription regulation
Function
P2Y(12) purinergic receptor, adenylyl cyclases (i.e., AC4, AC6, and AC8), and protein kinase A (i.e., PKA RI-beta and PKA RII-alpha regulatory subunits), exchange protein directly activated by cAMP (EPAC) isoform 2, and A-kinase anchoring proteins (i.e., AKAP150) are expressed in cholangiocyte cilia.
Model organism evidence
Mus musculus (3 references)
The melanocortin system centrally regulates energy homeostasis, with key components such as melanocortin-4 receptor (MC4R) and adenylyl cyclase 3 (ADCY3) in neuronal primary cilia.
Ciliary localization of GPR75 promotes fat accumulation in mice.