ADGB

androglobin

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000118492
UniProt:: Q8N7X0
OMIM:: 614630
Synonyms:: C6ORF103, CAPN16, DJ408K24.1, FLJ23121

Cilia effects upon perturbation of ADGB

Cilia number / % ciliated:: Incrased cilia number
Overexpression effect:: Increased

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.21) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: no spontaneous movement, increased eosinophil cell number, increased skeletal muscle mass, abnormal eye morphology, increased freezing behavior, atrophy

Subcellular localization

cilia, ciliary tip, axoneme

References: PMID:42010243, PMID:33453283

Functional category

Ciliary assembly/disassembly
Reproduction & sperm

Function

ADGB-dependent increase in the number of ciliated cells upon overexpression of the full-length protein, confirming a ciliogenesis-associated role of ADGB in mammals(33453283).

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