ADGB
androglobin
- Ensembl:
- ENSG00000118492
- UniProt:
- Q8N7X0
- OMIM:
- 614630
- Synonyms:
- C6ORF103, CAPN16, DJ408K24.1, FLJ23121
Cilia effects upon perturbation of ADGB
- Cilia number / % ciliated:
- Incrased cilia number
- Overexpression effect:
- Increased
Ciliogenesis screen results (2 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.21) PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Phenotypes
- Mouse phenotype:
- no spontaneous movement, increased eosinophil cell number, increased skeletal muscle mass, abnormal eye morphology, increased freezing behavior, atrophy
- Mouse ciliopathy phenotype:
- male infertility, abnormal brain morphology, hydrocephalus, abnormal kidney morphology, hydrocephaly
Subcellular localization
cilia associated gene
Functional category
- Ciliary assembly/disassembly
- Reproduction & sperm
Function
ADGB-dependent increase in the number of ciliated cells upon overexpression of the full-length protein, confirming a ciliogenesis-associated role of ADGB in mammals(33453283).
Model organism evidence
Mus musculus (4 references)
Collectively, our data indicate that ADGB is strongly regulated at the transcriptional level and might have functions beyond ciliogenesis.
OBJECTIVES: In male mice, adgb-knockout has been reported to cause male infertility with spermatogenesis defects involving flagella and acrosome.
Danio rerio (1 reference)
Ablation or targeted mutation of Foxj1 in mice, zebrafish and frogs results in loss of ciliary motility and/or reduced length and number of motile cilia, affecting the establishment of the left-right axis.
PMIDs: 37158461