ADM

adrenomedullin

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000148926
UniProt:
P35318
OMIM:
103275
Synonyms:
AM

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.56) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Longer Cilia (Area per Cilia z=2.93) PMID:20393562

Subcellular localization

No ciliary localization reported (cilia-associated gene).

References: PMID:26481478

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Muscle contraction & physiology

Function

The vertebrate/human-type vasoactive molecule adrenomedullin (ADM) and its close relative compounds (PAMP and CGRP) have ligand-specific, diverse effects on the migratory behaviour of the eukaryotic ciliate Tetrahyme piriformis ( 26481478).