ADNP

activity dependent neuroprotector homeobox

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000101126
UniProt:: Q9H2P0
OMIM:: 611386
Synonyms:: ADNP1, KIAA0784

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-8.89) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Human ciliopathy phenotype:: ADNP-related multiple congenital anomalies - intellectual disability - autism spectrum disorder; ADNP-related multiple congenital anomalies-intellectual disability-autism spectrum disorder; Intellectual disability

Subcellular localization

basal body, cilia, nucleus, ciliary tip, motile cilia

References: PMID:41005307, PMID:39677731

Functional category

Ciliary assembly/disassembly
Neurogenesis & migration

Function

ADNP has localized in basal body, cilia. GFP-tagged ADNP, an autism-associated chromatin regulator, localizes to motile cilia (Kostyanovskaya et al., 2025, bioRxiv, PMID 39677731).

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