ADORA2A

adenosine A2a receptor

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000128271
UniProt:
P29274
OMIM:
102776
Synonyms:
ADORA2, RDC8

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.42) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
decreased lean body mass, increased circulating glucose level, increased total body fat amount, increased neutrophil cell number, decreased hemoglobin content, decreased lymphocyte cell number, increased freezing behavior, decreased locomotor activity

Subcellular localization

cilia, lysosomes

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

ADORA2A has localized in cilia.