ADORA2B

adenosine A2b receptor

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000170425
UniProt:
P29275
OMIM:
600446

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
increased circulating alkaline phosphatase level, decreased circulating glucose level, increased fasting circulating glucose level

Subcellular localization

cilia, ciliary tip

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Muscle contraction & physiology

Function

ADORA2B has localized in cilia.