ADRB2

Cilia effects upon perturbation of ADRB2

Loss-of-function effect:

Shorter cilia

Ciliogenesis screen results (5 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.52) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
• Kim et al. 2010 (siRNA) [siRNA]: Longer Cilia (Area per Cilia z=3.13) PMID:20393562

Phenotypes

Mouse phenotype:

enlarged spleen, abnormal eye morphology, small liver, abnormal spleen morphology, abnormal skin morphology

Mouse ciliopathy phenotype:

enlarged kidney, abnormal liver morphology, abnormal kidney morphology, abnormal auditory brainstem response

Human ciliopathy phenotype:

sinusitis

Subcellular localization

cilia, endosome, nucleus

Functional category

• Ciliary assembly/disassembly
• T cell biology
• Protein processing & maturation
• Signaling (Hedgehog, GPCRs, ion channels)
• Cardiac & muscle development
• Muscle contraction & physiology

Function

Multiple GPCRs localized to cilia in mouse and human islet α and β cells, including FFAR4, PTGER4, ADRB2, KISS1R, and P2RY14(34385262).

Model organism evidence