ADRB2

adrenoceptor beta 2

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000169252
UniProt:
P07550
OMIM:
109690
Synonyms:
ADRB2R, ADRBR, ARB2, B2AR, BAR

Cilia effects upon perturbation of ADRB2

Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.52) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Kim et al. 2010 (siRNA) [siRNA]: Longer Cilia (Area per Cilia z=3.13) PMID:20393562

Phenotypes

Mouse phenotype:
enlarged spleen, abnormal eye morphology, small liver, abnormal spleen morphology, abnormal skin morphology
Human ciliopathy phenotype:
sinusitis

Subcellular localization

cilia, endosome, nucleus, basal body

References: PMID:41005307, PMID:34385262

Functional category

  • Ciliary assembly/disassembly
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Muscle contraction & physiology

Function

Multiple GPCRs localized to cilia in mouse and human islet α and β cells, including FFAR4, PTGER4, ADRB2, KISS1R, and P2RY14(34385262).