AGO2

argonaute RISC catalytic component 2

Ensembl:: ENSG00000123908
UniProt:: Q9UKV8
OMIM:: 606229
Synonyms:: CASC7, EIF2C2, HAGO2, LINC00980, Q10

Cilia effects upon perturbation of AGO2

Loss-of-function effect:: Shorter cilia

Ciliogenesis screen results (2 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.45) PMID:41160700

Subcellular localization

basal body, cilia, cytosol, nucleus, p-body

Functional category

Ciliary assembly/disassembly
Protein processing & maturation
Cell migration & adhesion
Signaling (Hedgehog, GPCRs, ion channels)
Transcription regulation

Function

hAgo2 localized to the proximal portion of the shaft of the primary cilium and localized to the basal body of primary human astrocytes as well as human synoviocytes during interphase and specifically with the distal end of the basal body in the pericentriolar region (21880135).

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.