AGTPBP1
ATP/GTP binding carboxypeptidase 1
- Ensembl:
- ENSG00000135049
- UniProt:
- Q9UPW5
- OMIM:
- 606830
- Synonyms:
- CCP1, KIAA1035, NNA1, CCPP1
Cilia effects upon perturbation of AGTPBP1
- Loss-of-function effect:
- Shorter cilia
Ciliogenesis screen results (3 screens)
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Subcellular localization
basal body, cilia, cytosol, nucleus
Functional category
- Ciliary assembly/disassembly
- Actin & cytoskeleton regulation
- Metabolism
- Signaling (Hedgehog, GPCRs, ion channels)
Function
AGTPBP1 has localized in basal body , primary cilia.
Model organism evidence
C. elegans (5 references)
Intraflagellar transport (IFT) involves the coordinated transport of molecular motors and other proteins and is required for ciliogenesis and ciliary maintenance.
Ciliopathies are often caused by defects in the ciliary microtubule core.