AGTPBP1

ATP/GTP binding carboxypeptidase 1

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000135049
UniProt:
Q9UPW5
OMIM:
606830
Synonyms:
CCP1, KIAA1035, NNA1, CCPP1

Cilia effects upon perturbation of AGTPBP1

Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, cilia, cytosol, nucleus

References: PMID:41005307

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Metabolism
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

AGTPBP1 has localized in basal body , primary cilia.