AHR

aryl hydrocarbon receptor

Ensembl:: ENSG00000106546
UniProt:: P35869
OMIM:: 600253
Synonyms:: BHLHE76

Cilia effects upon perturbation of AHR

Ciliogenesis screen results (4 screens)

Kim2016: No effect
Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Human ciliopathy phenotype:: retinitis pigmentosa

Subcellular localization

cilia associated gene, cytosol, nucleus

Functional category

Ciliary assembly/disassembly
T cell biology
Signaling (Hedgehog, GPCRs, ion channels)
Transcription regulation

Function

AhR deficiency affects both multiciliated cell commitment and cilia organization. In the presence of a Notch inhibitor, AhR agonists are still unable to trigger Ccno induction, indicating that Notch signals are not sufficient to provide the specificity for AhR-induced ciliogenesis. ( 27554288).

Note: Additional interactive sections (perturbation matrix visualization, phylogenetic conservation strip, protein complex network, STRING interactions) require JavaScript. Browse CiliaHub for the full experience.