AJUBA

ajuba LIM protein

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000129474
UniProt:: Q96IF1
OMIM:: 609066
Synonyms:: JUB, MGC15563

Ciliogenesis screen results (2 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (z=3.23) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:: increased circulating alkaline phosphatase level, decreased lymphocyte cell number, abnormal autopod morphology, increased grip strength, increased spleen weight, increased neutrophil cell number, abnormal digit morphology, increased freezing behavior

Subcellular localization

basal body, cytosol, nucleus, p-body

References: PMID:20457130

Functional category

Ciliary assembly/disassembly
Actin & cytoskeleton regulation

Function

GFP-Ajuba co-localized with the centrosome/basal body marker γ-tubulin, although additional GFP-Ajuba granules could be seen scattered in the cytoplasm(20457130)

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