AJUBA

ajuba LIM protein

Ensembl:
ENSG00000129474
UniProt:
Q96IF1
OMIM:
609066
Synonyms:
JUB, MGC15563

Cilia effects upon perturbation of AJUBA

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (z=3.23) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
increased circulating alkaline phosphatase level, decreased lymphocyte cell number, abnormal autopod morphology, increased grip strength, increased spleen weight, increased neutrophil cell number, abnormal digit morphology, increased freezing behavior

Subcellular localization

basal body, cytosol, nucleus, p-body

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation

Function

GFP-Ajuba co-localized with the centrosome/basal body marker γ-tubulin, although additional GFP-Ajuba granules could be seen scattered in the cytoplasm(20457130)

Model organism evidence

Danio rerio (1 reference)

Wtip is an LIM domain protein of the Ajuba/Zyxin family, but its role in ciliogenesis during embryonic development has not been previously described.

PMIDs: 23213452