AK1

adenylate kinase 1

Ensembl:
ENSG00000106992
UniProt:
P00568
OMIM:
103000
Synonyms:
ADK, ADK1

Cilia effects upon perturbation of AK1

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Metabolism
  • Reproduction & sperm

Function

Western blotting analyses showed that AK1 is localized at the cilia, and AK2 is mainly located in the cytoplasm. In our phosphoarginine shuttle model(24726623).

Model organism evidence

Mus musculus (1 reference)

The association of ODF4 with AK1 and AK2 in mice is essential for fertility through its contribution to flagellar shape.

PMIDs: 36804949