AK9

adenylate kinase 9

Ensembl:
ENSG00000155085
UniProt:
Q5TCS8
OMIM:
615358
Synonyms:
AKD1, AKD2, C6ORF199, C6ORF224, DJ70A9.1

Cilia effects upon perturbation of AK9

Ciliogenesis screen results (2 screens)

  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.82) PMID:41160700

Subcellular localization

cilia, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Metabolism

Function

Six of the iNPH-associated proteins examined (Cwh43, Rxfp2, Ak9, HAVCR1/Kim1, spatacsin, and myo7A) localized to ependymal motile cilia in vivo or in cultured mouse ependymal cells (38100419).

Model organism evidence

Mus musculus (1 reference)

Mice homozygous for an iNPH-associated AK9 mutation displayed normal cilia structure and number, but decreased cilia motility and beat frequency, communicating hydrocephalus, and balance impairment.

PMIDs: 38100419