AK9

adenylate kinase 9

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000155085
UniProt:: Q5TCS8
OMIM:: 615358
Synonyms:: AKD1, AKD2, C6ORF199, C6ORF224, DJ70A9.1, FLJ25791, FLJ42177, MGC26954

Ciliogenesis screen results (2 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.82) PMID:41160700

Subcellular localization

cilia, nucleus

References: PMID:41410385, PMID:38100419, PMID:39743588

Functional category

Ciliary assembly/disassembly
Metabolism

Function

Six of the iNPH-associated proteins examined (Cwh43, Rxfp2, Ak9, HAVCR1/Kim1, spatacsin, and myo7A) localized to ependymal motile cilia in vivo or in cultured mouse ependymal cells (38100419). Identified by cryo-EM as a component of radial spoke 3 in sperm flagella and other motile cilia (Leung et al., 2025, Nature, PMID 39743588).

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