AKAP2
A-kinase anchoring protein 2
Tier: Gold Standard Ciliary Genes
- Ensembl:
- ENSG00000241978
- UniProt:
- Q9Y2D5
- OMIM:
- 604582
- Synonyms:
- AKAPKL, AKAP-KL, PRKA2
Cilia effects upon perturbation of AKAP2
- Loss-of-function effect:
- Ciliogenesis defects (AKAP2 deletion in cells; depletion in medaka)
Subcellular localization
cilia
References: PMID:42897536
Functional category
- Signaling (Hedgehog, GPCRs, ion channels)
Function
AKAP2 (A-kinase anchoring protein 2) dynamically localizes within the primary cilium and forms complexes with kinesin motors and intraflagellar transport components. The AKAP2/PKA complex controls cilium biogenesis and intraciliary trafficking of cargo receptors and acts as a positive regulator of Shh signaling; AKAP2 depletion in medaka impairs ciliogenesis and ciliary trafficking, delays development and increases embryonic death (PMID 42897536).