AKAP3

A-kinase anchoring protein 3

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000111254
UniProt:
O75969
OMIM:
604689
Synonyms:
AKAP110, CT82, FSP95, SOB1

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

flagella, nucleus

References: PMID:15257753, PMID:11229805

Functional category

  • Actin & cytoskeleton regulation
  • Reproduction & sperm
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

N-terminal domain of Sp17 binds the RII binding domain of AKAP3 along the length of the flagella in spermatozoa (15257753) , AKAP3 and AKAP4 localized correctly to the FS of the amorphous flagellum in DFS sperm.