AKT1

AKT serine/threonine kinase 1

Ensembl:
ENSG00000142208
UniProt:
P31749
Synonyms:
AKT, PKB, PRKBA, RAC, RAC-ALPHA

Cilia effects upon perturbation of AKT1

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (5 screens)

  • Kim2016: Decreased cilia numbers
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.07) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Joubert Candidate / Ciliogenesis Defect (robust z=-3.28, ciliated=12.5%) PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.19) PMID:41160700

Phenotypes

Human ciliopathy phenotype:
clear cell renal carcinoma

Subcellular localization

basal body, cilia, cytosol, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation
  • T cell biology
  • Reproduction & sperm
  • Viral interactions
  • Protein processing & maturation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development
  • Transcription regulation

Function

Neddylation inhibitor MLN4924 suppresses cilia formation by modulating AKT1. Regulates a Rab11- Effector Switch Required for Ciliogenesis(31204173).