ALDOB

aldolase, fructose-bisphosphate B

Ensembl:: ENSG00000136872
UniProt:: P05062
OMIM:: 612724

Cilia effects upon perturbation of ALDOB

Ciliogenesis screen results (4 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.18) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: preweaning lethality, incomplete penetrance, decreased body length, abnormal heart left ventricle morphology, decreased bone mineral density

Subcellular localization

basal body, centrosome, cytosol

Functional category

Ciliary assembly/disassembly
Metabolism

Function

ALDOB interacts with BBS proteins (BBS1/2/4/7) has been confirmed , even if ALDOB expression did not overlap with gama-tubulin, it was found adjacent to the centrosome, possibly associated in part to the centriolar satellites ( 18000879)

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