ALG5

ALG5 dolichyl-phosphate beta-glucosyltransferase

Ensembl:
ENSG00000120697
UniProt:
Q9Y673
OMIM:
604565
Synonyms:
BA421P11.2

Cilia effects upon perturbation of ALG5

Ciliogenesis screen results (6 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=54, lfc=0.89) PMID:30270045
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-4.49) PMID:41160700

Phenotypes

Human ciliopathy phenotype:
polycystic kidney disease 7

Ciliopathy associations

  • Autosomal Dominant Polycystic Kidney Disease

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly

Function

Mutations in the ALG5 gene cause Autosomal Dominant Polycystic Kidney Disease (PMID: 35896117).