ALOX15

arachidonate 15-lipoxygenase

Ensembl:
ENSG00000161905
UniProt:
P16050
OMIM:
152392
Synonyms:
15-LOX-1

Cilia effects upon perturbation of ALOX15

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.37) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia

Function

ALOX15 has located to motile cilia.

Model organism evidence

Mus musculus (2 references)

The genes uncovered by the screen included genes that regulate ciliogenesis and cilia-transduced cell signaling as well as many that mediate endocytic trafficking, a cell process critical for both ciliogenesis and cell signaling.

Bridge-like lipid transfer protein family member 2 suppresses ciliogenesis.

PMIDs: 38724024, 38536441

Drosophila (1 reference)

Bridge-like lipid transfer protein family member 2 suppresses ciliogenesis.

PMIDs: 38536441