ANK2

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000145362
UniProt:: Q01484
OMIM:: 106410
Synonyms:: ankyrin-2, ankyrin-B, ANK-2, ankyrin 2

Cilia effects upon perturbation of ANK2

Cilia number / % ciliated:: Decreased cilia number

Subcellular localization

cilia

References: doi:10.1126/sciadv.aed5548, PMID:39677731, PMID:26638075

Function

Ankyrin-2 (ankyrin-B), a membrane-cytoskeletal adaptor. Validated by immunostaining on neuronal cilia (Chang et al. 2026, Sci Adv), where it scaffolds the ciliary Na+/K+-ATPase and may anchor signalling nanodomains. Antibody staining in rat brain cells confirms ciliary localization of ANK2 (Kostyanovskaya et al., 2025, bioRxiv, PMID 39677731). ANK2 localizes to cilia, and ANK2 knockdown suppresses centriole amplification, reduces ciliation and perturbs centriolar satellite morphology in human epithelial cells (Gupta et al., 2015, Cell, PMID 26638075).

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