ANKEF1

ankyrin repeat and EF-hand domain containing 1

Ensembl:
ENSG00000132623
UniProt:
Q9NU02
Synonyms:
ANKRD5, DJ839B4.6, FLJ21669

Cilia effects upon perturbation of ANKEF1

Ciliogenesis screen results (2 screens)

  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=575, lfc=0.47) PMID:30270045

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly

Function

ankef1a, odf3l2a, and saxo2 have distinct distribution patterns within the kinocilium (37367482).

Model organism evidence

Mus musculus (1 reference)

Furthermore, we found that Ankef1a, Odf3l2a, and Saxo2 exhibit distinct localization patterns along the length of the kinocilium and within the cell body.

PMIDs: 37367482

Danio rerio (2 references)

Furthermore, we found that Ankef1a, Odf3l2a, and Saxo2 exhibit distinct localization patterns along the length of the kinocilium and within the cell body.

Recent human next-generation sequencing (NGS) studies indicate a correlation between ANKEF1 (ankyrin repeat and EF-hand domain containing protein 1) expression and cilia formation or function.

PMIDs: 37367482, 31520739

Xenopus (1 reference)

Recent human next-generation sequencing (NGS) studies indicate a correlation between ANKEF1 (ankyrin repeat and EF-hand domain containing protein 1) expression and cilia formation or function.

PMIDs: 31520739