ANKEF1

ankyrin repeat and EF-hand domain containing 1

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000132623
UniProt:: Q9NU02
Synonyms:: ANKRD5, DJ839B4.6, FLJ21669

Ciliogenesis screen results (2 screens)

Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=575, lfc=0.47) PMID:30270045

Subcellular localization

cilia

References: PMID:37367482, PMID:39743588

Functional category

Ciliary assembly/disassembly

Function

ankef1a, odf3l2a, and saxo2 have distinct distribution patterns within the kinocilium (37367482). Identified by cryo-EM as a component of the nexin-dynein regulatory complex in sperm flagella and other motile cilia (Leung et al., 2025, Nature, PMID 39743588).

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