ANKH

ANKH inorganic pyrophosphate transport regulator

Ensembl:
ENSG00000154122
UniProt:
Q9HCJ1
OMIM:
605145
Synonyms:
ANK, CCAL2, CMDJ, CPPDD, HANK

Cilia effects upon perturbation of ANKH

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.11) PMID:41160700

Subcellular localization

basal body, cilia

Functional category

  • Ciliary assembly/disassembly

Function

ANKH localized at cilial and basal body in re l tissues and re l epithelial cells, in addition to a centrosomal localisation in dividing mpkCCDcl4 cells. and postulate a sensory role at this location(19910700).

Model organism evidence

Mus musculus (1 reference)

The pyrophosphate transporter ANKH is expressed in kidney and bone cells and colocalises to the primary cilium/basal body complex.

PMIDs: 19910700