ANKH

ANKH inorganic pyrophosphate transport regulator

Tier: Gold Standard Ciliary Genes

Ensembl:: ENSG00000154122
UniProt:: Q9HCJ1
OMIM:: 605145
Synonyms:: ANK, CCAL2, CMDJ, CPPDD, HANK, SLC62A1

Ciliogenesis screen results (5 screens)

Kim2016: Not Reported
Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.11) PMID:41160700

Subcellular localization

basal body, cilia

References: PMID:19910700

Functional category

Ciliary assembly/disassembly

Function

ANKH localized at cilial and basal body in renal tissues and renal epithelial cells, in addition to a centrosomal localisation in dividing mpkCCDcl4 cells. and postulate a sensory role at this location(19910700).

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