ANKMY2

Cilia effects upon perturbation of ANKMY2

Loss-of-function effect:

Shorter cilia

Ciliogenesis screen results (3 screens)

• Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

abnormal embryo development, abnormal embryo size, embryonic growth retardation, abnormal forebrain development, abnormal somite shape, preweaning lethality, complete penetrance, abnormal placenta development, pretal lethality prior to heart atrial septation, abnormal placenta size, abnormal hindbrain development, abnormal neural tube morphology, abnormal pharyngeal arch morphology, pallor, abnormal vitelline vasculature morphology

Subcellular localization

cilia

References: PMID:21124868, PMID:41474822

Functional category

• Ciliary assembly/disassembly
• Signaling (Hedgehog, GPCRs, ion channels)

Function

DAF-25(C. elegans ortholog of mammalian Ankmy2), which localizes to sensory cilia, is required for proper DAF-11 ciliary localization, mouse Ankmy2 interacts with guanylyl cyclase GC1 from ciliary photoreceptors, ciliary localization of DAF-25 itself is influenced in che-11 mutants (21124868)