ANKRD26
ankyrin repeat domain containing 26
- Ensembl:
- ENSG00000107890
- UniProt:
- Q9UPS8
- OMIM:
- 610855
- Synonyms:
- KIAA1074, THC2
Cilia effects upon perturbation of ANKRD26
- Cilia number / % ciliated:
- Decreased cilia number
- Loss-of-function effect:
- Shorter cilia
Ciliogenesis screen results (5 screens)
- Kim2016: Not Reported
- Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
- Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
- Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
- Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.44) PMID:41160700
Subcellular localization
basal body, centrosome
Functional category
- Ciliary assembly/disassembly
- Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
- T cell biology
Function
Ankrd26-/- mice display hyperphagia and have defects in primary cilia in regions of the central nervous system that control appetite and energy homeostasis (24633808). With TALPID3 selectively orchestrates FBF1 localization and cilia gating (32366837)
Model organism evidence
C. elegans (2 references)
Genetic analysis reveals that TALP-3 coordinates with ANKR-26, the homolog of ANKRD26, to orchestrate proper cilia gating. Co-depletion of TALP-3 and ANKR-26 specifically impairs the recruitment of DYF-19 to transition fibers.
While DZIP-1 or ANKR-26 (the ortholog of ANKRD26) deficiency shows subtle impact on transition fibers, co-depletion of DZIP-1 and ANKR-26 disrupts TF assembly and cilia gating for soluble and membrane proteins.