ANKRD26

ankyrin repeat domain containing 26

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000107890
UniProt:
Q9UPS8
OMIM:
610855
Synonyms:
KIAA1074, THC2

Cilia effects upon perturbation of ANKRD26

Cilia number / % ciliated:
Decreased cilia number
Loss-of-function effect:
Shorter cilia

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-3.44) PMID:41160700

Subcellular localization

basal body, centrosome

References: PMID:24633808, PMID:32366837

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

Ankrd26-/- mice display hyperphagia and have defects in primary cilia in regions of the central nervous system that control appetite and energy homeostasis (24633808). With TALPID3 selectively orchestrates FBF1 localization and cilia gating (32366837)