ANO1

anoctamin 1

Ensembl:
ENSG00000131620
UniProt:
Q5XXA6
OMIM:
610108
Synonyms:
DOG1, FLJ10261, ORAOV2, TAOS2, TMEM16A

Cilia effects upon perturbation of ANO1

Loss-of-function effect:
Longer cilia

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.70) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.24) PMID:41160700

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

TMEM16A. Ca2+-activated Cl- channel .Regulates primary ciliogenesis(24694595).