ANO2

anoctamin 2

Ensembl:
ENSG00000047617
UniProt:
Q9NQ90
OMIM:
610109
Synonyms:
C12ORF3, TMEM16B

Cilia effects upon perturbation of ANO2

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Phenotypes

Mouse phenotype:
hyperactivity, decreased anxiety-related response, enlarged thymus, abnormal lymph node morphology, abnormal behavior, abnormal digit morphology, decreased thigmotaxis, abnormal thymus morphology, enlarged lymph nodes

Subcellular localization

cilia, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Viral interactions
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Localises to cilia of olfactory epithelium(19561302).