ANXA1

annexin A1

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000135046
UniProt:
P04083
OMIM:
151690
Synonyms:
ANX1, LPC1

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.83) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
abnormal spleen morphology, increased airway resistance, abnormal thymus morphology, enlarged spleen, abnormal epididymis morphology, enlarged thymus, small spleen, enlarged uterus, enlarged epididymis, decreased circulating iron level

Subcellular localization

cilia, nucleus

References: PMID:24748648

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

In frog olfactory epithelia, ANXA isoforms 1, 2, and 5 bind to dicalcin in a Ca2+-dependent manner (17714509). ANXA1, ANXA2, ANXA5, S100A5, PMCA1, and NCKX4 in the cilia of mouse OSNs (24748648).