ANXA1

Cilia effects upon perturbation of ANXA1

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.83) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

abnormal spleen morphology, increased airway resistance, abnormal thymus morphology, enlarged spleen, abnormal epididymis morphology, enlarged thymus, small spleen, enlarged uterus, enlarged epididymis, decreased circulating iron level

Mouse ciliopathy phenotype:

enlarged heart, small kidney, abnormal uterus morphology, abnormal heart morphology, increased circulating alanine transamise level

Subcellular localization

cilia, nucleus

Functional category

• Ciliary assembly/disassembly
• Actin & cytoskeleton regulation
• T cell biology
• Cell migration & adhesion
• Signaling (Hedgehog, GPCRs, ion channels)

Function

In frog olfactory epithelia, ANXA isoforms 1, 2, and 5 bind to dicalcin in a Ca2+-dependent manner (17714509). ANXA1, ANXA2, ANXA5, S100A5, PMCA1, and NCKX4 in the cilia of mouse OSNs (24748648).