ANXA2

annexin A2

Ensembl:
ENSG00000182718
UniProt:
P07355
OMIM:
151740
Synonyms:
ANX2, ANX2L4, CAL1H, LIP2, LPC2D

Cilia effects upon perturbation of ANXA2

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.93) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

cilia, endosome, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Neurogenesis & migration
  • Protein processing & maturation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

ANXA2 together with S100A10 protein interacts with + (12050667) , K+ (12198146), and Ca2+ channels (12660155) to regulate their translocation and function. In frog olfactory epithelia, ANXA isoforms 1, 2, and 5 bind to dicalcin in a Ca2+-dependent manner(17714509). ANXA1, ANXA2, ANXA5, S100A5, PMCA1, and NCKX4 in the cilia of mouse OSNs (24748648).