APC

APC regulator of WNT signaling pathway

Tier: Cilia-Associated Genes

Ensembl:
ENSG00000134982
UniProt:
P25054
OMIM:
611731
Synonyms:
DP2, DP2.5, DP3, PPP1R46

Cilia effects upon perturbation of APC

Cilia number / % ciliated:
No effect
Loss-of-function effect:
Longer cilia

Ciliogenesis screen results (5 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-5.17) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381
  • Pusapati et al. 2018 (CRISPR) [CRISPR]: Negative Regulator (Hh signaling, pos_rank=730, lfc=0.71) PMID:30270045

Subcellular localization

basal body, Centrosome, Cytosol, Microtubules, Nucleus

References: PMID:25139956

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

No ciliary evidence specific to APC (adenomatous polyposis coli). The ciliary-polarity phenotype previously recorded here belongs to ANAPC2, the cullin subunit of the anaphase-promoting complex, whose HGNC alias is APC2 (Ganner et al. 2009, PMID 19805045). Retained on the basis of lof_effect = 'Longer cilia' in functional screens.