APC2

APC regulator of WNT signaling pathway 2

Ensembl:
ENSG00000115266
UniProt:
O95996
OMIM:
612034
Synonyms:
APCL

Cilia effects upon perturbation of APC2

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.21) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=3.55, ciliated=64.8%) PMID:26595381

Subcellular localization

basal body

Functional category

  • Ciliary assembly/disassembly
  • Trafficking (BBSome, small GTPases, vesicular transport, ATPases)
  • Actin & cytoskeleton regulation

Function

APC subunit 2 (APC2) is localized to the basal body of the ciliated cells (25139956), consistent with the previous report that APC is localized to the basal body of motile cilia in the Xenopus epidermis (Ganner et al., 2009).

Model organism evidence

Mus musculus (1 reference)

Desulfovibrio vulgaris flagellin exacerbates colorectal cancer through activating LRRC19/TRAF6/TAK1 pathway.

PMIDs: 39718561