APC2

APC regulator of Wnt signaling pathway 2

Tier: Gold Standard Ciliary Genes

Ensembl:
ENSG00000115266
UniProt:
O95996
OMIM:
612034
Synonyms:
APCL

Ciliogenesis screen results (4 screens)

  • Kim2016: No effect
  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-4.21) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: Hyper-ciliogenesis (robust z=3.55, ciliated=64.8%) PMID:26595381

Subcellular localization

cilia

References: PMID:41005307, PMID:25139956, PMID:19805045

Function

Detected in the primary cilium by antibody-based spatial proteomics of human cell lines (Hansen et al. 2025, Cell, PMID 41005307).