APLNR

apelin receptor

Ensembl:
ENSG00000134817
UniProt:
P35414
OMIM:
600052
Synonyms:
AGTRL1, APJ, APJR, FLJ90771

Cilia effects upon perturbation of APLNR

Ciliogenesis screen results (3 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-6.70) PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Elliott et al. 2025 (CRISPRa) [CRISPRa]: Disassembly Trigger (casTLE Effect=-2.01) PMID:41160700

Phenotypes

Mouse phenotype:
preweaning lethality, incomplete penetrance, decreased prepulse inhibition, abnormal epididymis morphology, abnormal eye morphology
Mouse ciliopathy phenotype:
abnormal kidney morphology

Subcellular localization

cilia associated gene

Functional category

  • Ciliary assembly/disassembly
  • Signaling (Hedgehog, GPCRs, ion channels)
  • Cardiac & muscle development

Function

During gastrulation and early somitogenesis, aplnra/b loss of function results in heart and liver LR asymmetry defects, accompanied by disturbed KV/cilia morphogenesis and disrupted left-sided Nodal/spaw expression in the LPM. In this process, only aplnra loss of function results in KV/cilia morphogenesis defect ( 31223282).