APPL1

adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1

Ensembl:
ENSG00000157500
UniProt:
Q9UKG1
OMIM:
604299
Synonyms:
APPL

Cilia effects upon perturbation of APPL1

Ciliogenesis screen results (2 screens)

  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680

Subcellular localization

basal body, cilia, cytosol, endosome, nucleus

Functional category

  • Ciliary assembly/disassembly
  • Actin & cytoskeleton regulation
  • Cell migration & adhesion
  • Signaling (Hedgehog, GPCRs, ion channels)

Function

Ocrl1 co-localized with the endosomal proteins IPIP27 or Appl1 (22228094).