AQP3

Cilia effects upon perturbation of AQP3

Ciliogenesis screen results (4 screens)

• Kim2016: Not Reported
• Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-2.52) PMID:26167766
• Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
• Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:

increased circulating calcium level, increased blood urea nitrogen level, increased circulating serum albumin level, increased circulating total protein level, increased lean body mass, increased circulating alkaline phosphatase level, increased circulating hdl cholesterol level, increased circulating cholesterol level

Mouse ciliopathy phenotype:

increased circulating creatinine level

Subcellular localization

cilia

Functional category

• Ciliary assembly/disassembly

Function

In oviduct, AQP1, AQP3, AQP6, and AQP9 were strongly expressed especially in ciliated columnar epithelial cells (Fig. 4). Immunoreactivities of AQP1, AQP3, AQP6, and AQP9 were localized mainly to cilia and luminal surface of epithelial cells with a subtle subtype-specific difference. (33110949).