AQP6

aquaporin 6

Ensembl:
ENSG00000086159
UniProt:
Q13520
OMIM:
601383
Synonyms:
AQP2L

Cilia effects upon perturbation of AQP6

Ciliogenesis screen results (4 screens)

  • Kim2016: Not Reported
  • Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
  • Breslow et al. 2018 (CRISPR) [CRISPR]: No Significant Effect PMID:29459680
  • Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:
increased total reti thickness, increased circulating chloride level
Mouse ciliopathy phenotype:
abnormal kidney morphology

Subcellular localization

cilia

Functional category

  • Ciliary assembly/disassembly

Function

In oviduct, AQP1, AQP3, AQP6, and AQP9 were strongly expressed especially in ciliated columnar epithelial cells (Fig. 4). Immunoreactivities of AQP1, AQP3, AQP6, and AQP9 were localized mainly to cilia and luminal surface of epithelial cells with a subtle subtype-specific difference. (33110949).