ARHGAP1

Rho GTPase activating protein 1

Ensembl:: ENSG00000175220
UniProt:: Q07960
OMIM:: 602732
Synonyms:: CDC42GAP, P50RHOGAP, RHOGAP

Cilia effects upon perturbation of ARHGAP1

Cilia number / % ciliated:: No effect
Loss-of-function effect:: No effect

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: Ciliogenesis Defect (z=-8.94) PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: Increased Signaling (Negative Regulator) PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Subcellular localization

basal body, cytosol

Functional category

Ciliary assembly/disassembly
Trafficking (BBSome, small GTPases, vesicular transport, ATPases)

Function

Focused siRNA screen on these 6 candidate ARHGAPs (ARHGAP1, -5, -19, -21, -29, -35) conducted in control cells (UCL93), achieving knockdown of greater than 80% by qPCR. Of note, knockdown of ARHGAP5, -29, and -35 but not ARHGAP1, -19, and -21 was found to significantly reduce ciliogenesis (PMID: 32663194).

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