ARHGAP10

Rho GTPase activating protein 10

Tier: Cilia-Associated Genes

Ensembl:: ENSG00000071205
UniProt:: A1A4S6
OMIM:: 609746
Synonyms:: FLJ20896, FLJ41791, GRAF2

Ciliogenesis screen results (3 screens)

Wheway et al. 2015 (siRNA) [siRNA]: No effect PMID:26167766
Breslow et al. 2018 (CRISPR) [CRISPR]: Positive Regulator (Hh signaling, casTLE effect=-0.87) PMID:29459680
Roosing et al. 2015 (siRNA) [siRNA]: No effect PMID:26595381

Phenotypes

Mouse phenotype:: increased mean platelet volume; decreased body length; abnormal sternum morphology; abnormal skin morphology; enlarged lymph nodes; abnormal bone structure; abnormal ovary morphology

Ciliopathy associations

Nonsyndromic Tetralogy of Fallot

References: PMID:41280016

Subcellular localization

cell membrane, centrosome, cytosol, nuclear membrane, nucleoplasm

Functional category

Small GTPases

Function

Listed as novel Congenital Heart Disease (CHD) gene with Ciliopathy-like phenotypes, likely functions in Rho GTPase signaling pathway regulating the basal body/cilium(41280016).

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